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The main RuneScape Wiki has an article on: Blood-Rune
The Old School RuneScape Wiki also has an article on Blood-Rune.

The Blood-Rune is a rune used for many high level spells. These runes are used for the Wave spells and God Spells. They can be obtained by thieving the blood rune chests in the Chaos Druid Tower's ogre dungeon, pickpocketing heroes, and killing monsters - since they are not obtainable by other means, e.g. shops, they are difficult to amass in large numbers.

Below is a table of spells that use blood runes.

Magic level Spell name Description Runes required Experience
60 Claws of Guthix Summons the power of Guthix 4 air-runes, 1 fire-rune and 2 blood-runes
(Staff of Guthix & Guthix Cape required)
140
60 Saradomin Strike Summons the power of Saradomin 4 air-runes, 2 fire-rune and 2 blood-runes
(Staff of Saradomin & Saradomin Cape required)
140
60 Flames of Zamorak Summons the power of Zamorak 1 air-rune, 4 fire-runes and 2 blood-runes
(Staff of Zamorak & Zamorak Cape required)
140
62 Wind wave A strength 13 missile attack 5 air-runes and 1 blood-rune 144
65 Water wave A Strength 14 missile attack 7 water-runes, 5 air-runes and 1 blood-rune 150
70 Earth wave A strength 15 missile attack 7 earth-runes, 5 air-runes and 1 blood-rune 160
75 Fire wave A strength 16 missile attack 7 fire-runes, 5 air-runes and 1 blood-rune 170

Dropped by[]

They are dropped by:

Monster Combat level Quantity Rarity
Black demon 156, 176 5, 7 3Uncommon
Black Dragon 200 10 2Common
Chaos Dwarf 59 5 5Very rare
Darkwizard 13, 25 1 3Uncommon
Earth warrior 52 1 4Rare
Fire Giant 109 3 3Uncommon
Guard 27, 28 1 4Rare
Ice Giant 68 1 3Uncommon
Ice Warrior 57 1 4Rare
Moss Giant 62 1 4Rare
King Black Dragon 245 10 2Common
Necromancer 34 1 3Uncommon
Paladin 71 1 4Rare
Red Dragon 140 1 3Uncommon
Shadow Warrior 64 1 3Uncommon
Thug 18 1 4Rare

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