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The main RuneScape Wiki has an article on: Lockpick
The Old School RuneScape Wiki also has an article on Lockpick.

Lockpicks are items used to picklock doors more easily. They can be obtained from pick-pocketing rogues with level 32 Thieving, or they can be obtained from a spawn located in the Yanille Agility dungeon which requires accessing the room with a pile of rubble leading towards Salarin the Twisted. Accessing this room requires either 57 Agility via the rope obstacle, or 82 Thieving which is accomplished by picking the lock of the door south of the dungeon's rope obstacle, which is accessed by going down the stairs in the building located south of Yanille bank.

Required for[]

Lockpick is required for four doors and one chest in the game. They are:

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