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The main RuneScape Wiki has an article on: Soul-Rune
The Old School RuneScape Wiki also has an article on Soul-Rune.

A Soul-Rune is a rune used in high-level curse Magic spells.

It can only be obtained by purchasing it from the Magic Guild Shop in Yanille, which requires level 66 Magic to enter, or from other players.

Soul spells[]

Spell Magic level Magic experience Runes required
Vulnerability 66 152 5 Earth-Runes, 5 Water-Runes and 1 Soul-Rune
Enfeeble 73 166 8 earth-runes, 8 water-runes and 1 Soul-Rune
Stun 80 180 12 earth-runes, 12 water-runes and 1 Soul-Rune

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